Best message box use/font use?

What's the best way to use the arrow guide naturally?  I know one represents if you use a portrait and the other if you don't but upon testing on different size monitors maker doesn't adjust for this (I have a 17" and 22" monitor respectfully).  Given the sizes of monitors and hundreds of combinations of font sizes and such (and even the preview only uses the default font), what's the best way to go about this to make it universal for different size monitors?

I would recommend to make it fit on the smallest one you have.
Because the most PC user have small monitors. Me for example has a 21" and a 42" screen. 
But I made it on the 21" the way, it's easy to read. The bigger one is a bit too big maybe. 
But not everyone has great eyes, so it's allways better to be on the sure site. :) (\s/)

Would changing the resolution work (to match my 17"), really don't want to work the entire project on my laptop lol... man wish maker had word wrap

You can use this script for it:
http://rmrk.net/index.php?topic=44964.0

With that, you don't need to hit enter on any time. It makes an automatically line brake.
Works fine with different resolutions too. :) (\s/)

So basically I can write on one line and never hit enter (though personally I would so I can see the whole thing lol prior to running a test).  I wonder if this works with Yanfly's message script (more than 4 lines bigger box dialog)

You can try it out with Yanfly Message, never done so.
Or maybe I did, had so many combinations try out, that I fortgot about some things. :D
But Yanfly is one of the most compatible scripts, so it may should work. ;) (\s/)